Complement Factor H

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

Also Known As:

Factor H; Factor H, Complement; Complement factor H

Pharmalogical Action Categories:

Complement Inactivating Agents

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Serum Globulins: 555
      - Beta-Globulins: 159
        Complement Factor H: 1252
    - Immunoproteins: 43
      - Complement System Proteins: 34043
        Complement Inactivator Proteins
        Complement C3b Inactivator Proteins
        Complement Factor H: 1252
  - Globulins: 3119
    - Serum Globulins: 555
      - Beta-Globulins: 159
        Complement Factor H: 1252

Lori Reinhart-Mercer Selected Research

Lori Reinhart-Mercer Research Topics

Disease

Drug/Important Bio-Agent (IBA)